KMID : 0613820180280010017
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Journal of Life Science 2018 Volume.28 No. 1 p.17 ~ p.25
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Immunomodulatory Effects of ¥â-1,3/1,6-glucan and Lactobacillus plantarum LM1004 on Atopic Dermatitis Models
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Kim In-Sung
Kim Sung-Hak Kim Jeong-A Yu Da-Yoon Kim Gwang-Il Park Dong-Chan Lim Jong-Min Lee Sang-Suk Choi In-Soon Cho Kwang-Keun
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Abstract
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In this study, we examined the efficacy of the immune regulation of ¥â-1,3/1,6-glucan and Lactobacillus plantarum LM1004 on atopic dermatitis models. The oral administration of ¥â-1,3/1,6-glucan and L. plantarum LM1004 on mice significantly decreased the amount of scratching, leakage to evans blue, and concentrations of serum immunoglobulin E (IgE) and histamine compared with the atopic dermatitis?induced group. When atopic dermatitis was induced, the transcription factors (GATA-3, retinoic acid-related orphan receptor ¥ã T [ROR¥ãT]) and cytokines (interleukin-4 [IL-4], IL-17) of Th2 and Th17 cells were overexpressed at the transcriptional level, and they significantly decreased with oral administration of ¥â-1,3/1,6-glucan and L. plantarum LM1004. In addition, ¥â-1,3/1,6-glucan and L. plantarum LM1004 were shown to modulate the immune balance by increasing the expression of Th1 and Treg transcription (T-bet, forkhead box p3 [Foxp3]) and cytokines (interferon-¥ã [IFN-¥ã], transforming growth factor-¥â [TGF-¥â]). Galectin-9 and filaggrin were significantly lower in the atopic dermatitis?induced group and significantly higher in the ¥â-1,3/1,6-glucan-treated group. In contrast, thymic stromal lymphopoietin (TSLP) was highest in the atopic dermatitis?induced group, while mice that were orally administered ¥â-1,3/1,6-glucan and L. plantarum LM1004 showed similar TSLP levels to the control group. These results indicate that ¥â-1,3/1,6-glucan and L. plantarum LM1004 have immunomodulatory effects and atopic dermatitis improvement effects in an animal model of atopic dermatitis. Therefore, it is expected that ¥â-1,3/1,6-glucan and L. plantarum LM1004 can be used as natural materials in the treatment of atopic dermatitis.
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KEYWORD
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Atopic dermatitis, ¥â-Glucan, immunomodulatory, Lactobacillus plantrum LM1004
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